Maria Grazia Bellocchio completed her musical studies at the Conservatorio G. Verdi in Milan with Antonio Beltrami and Chiaralberta Pastorelli, continuing them at the Hochschule in Bern with Karl Engel and in Milan with Franco Gei.

In her first public appearances, she performed Scriabin's concert with the RAI Orchestra of Milan, Beethoven's first concert with the Orchestra of the Conservatory of Milan, and the Orchestra Sinfonica Siciliana and Strawinsky's Les Noces at the Teatro Comunale of Bologna.
Later, always as soloist, she has played with the Orchestra da camera di Pesaro, Milano Classica, Scottish Chamber Orchestra, Orchestra Toscanini di Parma, Orchestra da Camera di Padova and Orchestra Sinfonica G. Verdi of Milan.

She was invited to join the Schleswig Holstein Music Festival Orchestra conducted by Leonard Bernstein.

As a chamber musician she has played with S. Accardo, R. Filippini, B. Giuranna, F. Petracchi, S. Azzolini and many others. He plays regularly in a piano duo with Stefania Redaelli.

In 2011, on the occasion of the celebrations for the 150th anniversary of the unification of Italy, she conceived the project "Viaggio in Italia - Nuovo canzoniere popolare - 20 canzoni popolari transcribed by 20 composers", premiered at the Maggio Musicale Fiorentino and repeated at the festival Mito, Musica Insieme in Bologna and several other Italian cities.

She collaborates regularly with Divertimento Ensemble directed by Sandro Gorli. She has recorded CDs for Ricordi and Stradivarius with works by Bruno Maderna, Sandro Gorli, Franco Donatoni, Stefano Gervasoni, Federico Gardella, Stefano Bulfon, Marco Momi, Claudio Ambrosini and Ivan Fedele.

She teaches piano at the Conservatorio "G. Donizetti" in Bergamo and regularly holds piano and chamber music masterclasses for various Italian institutions.

In 2012 she conceived the project Call for Young Performers within IDEA, the academy of Divertimento Ensemble: a monographic course dedicated to contemporary literature for piano.